Effect of BMP-2 on apoptosis of hepatoma cells and its mechanisms
- VernacularTitle:骨形成蛋白2诱导肝癌细胞凋亡及其机制
- Author:
Siyuan TANG
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms/pathol;
Bone Morphogenetic protein-2;
Apoptosis
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of BMP-2 on apoptosis of human hepatoma HepG2 cells and the mechanisms.Methods Cell apoptosis was assessed by ELISA.Western blot was used to detect the expression of Bcl-2 and Fas proteins in HepG2 cells after treatment of BMP-2.Results 1～100ng/mL BMP-2 induced HepG2 cell apoptosis,and down-regulated Bcl-2 protein expression and increased Fas protein expression.Conclusions The present study suggests that BMP-2 induces HepG2 cell apoptosis may through Fas pathway.
