Effect of ERK1/2/c-Fos signal pathway on angiotensin-(1-7) inhibiting proliferation of rat glomerular mesangial cell strain induced by angiotensin Ⅱ
- VernacularTitle:ERK/c-Fos通路在Ang-(1-7)抑制Ang-Ⅱ诱导大鼠肾系膜细胞株增殖中的作用
- Author:
Hongyan HE
;
Ning SHEN
;
Jian LIU
;
Xiaoling SHI
;
Mingyong WANG
- Publication Type:Journal Article
- Keywords:
Mesangial cells;
Angiotensin Ⅱ;
Angiotensin-(1-7);
p-ERK1/2 signal transduction pathway;
Protein c-Fos
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of ERK1/2/c-Fos signal pathway during angiotensin-(1-7)inhibiting proliferation of rat glomerular mesangial cell strain(GMCS)induced by angiotensin Ⅱ.METHODS:Rat glomerular mesangial cells(GMC)were co-cultured with angiotensin Ⅱ and different doses of angiotensin-(1-7).The numbers of GMC were evaluated by crystal violet staining.The amounts of p-ERK1/2 and c-Fos expressions were detected by Western blotting.RESULTS:Angiotensin-(1-7)showed its inhibitory effects on GMC number increasing induced by angiotensin Ⅱ as well as the amounts of p-ERK1/2 and c-Fos expressions in a concentration dependent manner.CONCLUSION:ERK/c-Fos signal pathway is involved in the inhibitory effects of angiotensin-(1-7)on angiotensin Ⅱ-induced GMC proliferation.