Endoplasmic reticulum stress mediates the neurotoxic effect of misfolded proteins in neurodegenerative diseases
- VernacularTitle:内质网应激介导神经变性疾病错折叠蛋白的神经毒性
- Author:
Junpeng GAO
;
Dingfang CAI
- Publication Type:Journal Article
- Keywords:
Endoplasmic reticulum;
Protein folding;
Neurodegenerative diseases
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum(ER)stress can be caused by disturbances in the function of the ER with the accumulation of misfolded proteins.The ER response is characterized by unfolded protein response(UPR)causing translational attenuation,induction of ER chaperones and degradation of misfolded proteins.In case of prolonged or aggravated ER stress,cellular signals leading to apoptosis are activated.ER stress has been suggested to be involved in human neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as other disorders.Here we will discuss the neurotoxic effect of ER stress in these three major neurodegenerative diseases,and highlight current knowledge in this field that may reveal novel insight into disease mechanisms and help to design better therapies for these disorders.
