Behavior changes of learning and memory related to the levels of NO and nNOS in brain of rats with acute alcoholism
- VernacularTitle:急性乙醇中毒大鼠学习记忆行为的改变与脑组织NO和nNOS含量变化
- Author:
Shuang LI
;
Chunyang XU
;
Dongliang LI
;
Ailin DU
;
Xiaojuan LI
;
Ruifang HE
- Publication Type:Journal Article
- Keywords:
Ethanol;
Nitric oxide;
Nitric-oxide synthase;
Learning;
Memory;
Neurotoxicity
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:In order to investigate the molecular mechanism of alcoholism acting on learning and memory,the dysfunction of learning and memory function was observed and the content of nitric oxide(NO)and neuronal nitric oxide synthase(nNOS)were determined in rats with acute alcoholism.METHODS:The mature male Sprague-Dawley rats were randomly divided into two groups.The experimental group animals were intraperitoneally administered with ethanol.The control group animals were injected with saline in the same way.The tests of learning and memory were performed at Y-maze after 6 h.Then brains were removed and the content of NO in brain tissue and nNOS expression in hippocampus CA1,corpus striatum were determined,respectively.RESULTS:(1)The training times to reach qualifying standards of Y-maze in experimental group(34.33?13.04)were higher than those in control group(27.50?8.79,P
