Studies on the Recognition-behaviors of Molecularly Imprinted Polymerintroduced ?-cyclodextrin towards ?-blocked Reagents
- VernacularTitle:引入?-环糊精的分子烙印聚合物对?受体阻滞药的识别行为研究
- Author:
Jianfeng HE
- Publication Type:Journal Article
- Keywords:
Molecularly imprinted polymer;
?-cyclodextrin;
Carvedilol;
Metoprolol
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the preparation methods of drug-molecularly imprinted polymer in aqueous phase and the substrate-recognition behaviors of the polymers.METHODS:The ?-blocked reagents carvedilol and metoprolol molecularly imprinted polymers were successfully synthesized in aqueous phase by utilizing the polymerisable ?-cyclodextrin as functional monomer,N,N-methylene-bisacrylamide as crosslinker,respectively.The affinity and selectivity of imprinted polymers for the templates and its structural analogues were evaluated in acetonitrile-water solvent by equilibrium binding experiments.RESULTS:The carvedilol and metoprolol molecularly imprinted polymers exhibited higher substrate-selectivity and recognition ability toward template,and the adsorption behaviors of the imprinted polymers were same as the "key-lock"relation between the enzyme and the substrate,however,the blank polymer didn't.CONCLUSIONS:The studies provided a feasible way to prepare molecularly imprinted polymers for drugs molecules in aqueous phase with highly recognizing ability.
