Effect of Amylum Pregelatinisatum on the Dissolution of Calcium Dobesilate Capsule
- VernacularTitle:预胶化淀粉对羟苯磺酸钙胶囊溶出度的影响
- Author:
Hui LIU
;
Qiang LI
- Publication Type:Journal Article
- Keywords:
Amylum pregelatinisatum;
Calcium dobesilate capsule;
Angle of repose;
Dissolution
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effects of amylum pregelatinisatum on the dissolution of calcium dobesilate capsule.METHODS:The amount of amylum pregelatinisatum was optimized by means of the determination of angle of repose and the in vitro dissolution,using the single factor design.The comparisons of effects of different manufactory of amylum pregelatinisatum on formulation and dissolution of capsule were done.RESULTS:Amylum pregelatinisatum could improve significantly the fluidity of powder of capsule.The dissolution of calcium dobesilate capsule were decreased with the increment of amylum pregelatinisatum.It demonstrated that the fluidity of powder and dissolution of calcium dobesilate capsule were the best when the ratio of amylum pregelatinisatum and microcrystalline cellulose was 1∶3 and the amount of sodium carboxymethyl starch was 4 %.The different resource of amylum pregelatinisatum had great effect on the dissoution of the formulation.CONCLUSION:Amylum pregelatinisatum is a favourable filler adjuvant of capsule,but its quantity and the quality should make an optimization.
