Optimization of Preparation Technology of Oleum Baeckeae Oil-?-Cyclodextrin Inclusion Complex by Orthogonal Experiment
- VernacularTitle:正交试验优选岗松挥发油?-环糊精包合物的制备工艺
- Author:
Pingchuan JIANG
;
Shaojie MAI
- Publication Type:Journal Article
- Keywords:
Oleum Baeckeae oil;
?-cyclodextrin;
Inclusion complex;
Orthogonal experiment;
Preparation technology
- From:
China Pharmacy
2007;0(36):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the preparation technology of Oleum Baeckeae oil - ?-cyclodextrin inclusion complex. METHODS:The preparation technology for Oleum Baeckeae oil-?-cyclodextrin inclusion complex was optimized by orthogonal experiment taking the ratio of the Oleum Baeckeaee oil to ?-cyclodextrin, the temperature for clathration and the duration of stirring as three factors and with the utilization ratio of the essential oil in Oleum Baeckeae oil inclusion complex as index. RESULTS:The optimal technological condition was as follows:the ratio of the Oleum Baeckeae oil to ?-cyclodextrin in the inclusion complex was 1∶10; the temperature for clathration was 50℃, and the duration of stirring was 2 hours. Under this condition, the average utilization ratio of Oleum Baeckeae oil was as high as 81.90%. CONCLUSION:The optimized preparation technology of Oleum Baeckeae oil - ?-cyclodextrin inclusion complex is feasible and serves as reference for the enhancing of stability of Oleum Baeckeae oil preparation.
