Fas/APO-1, Caspase-3 and apoptosis of human middle ear cholesteatoma
- VernacularTitle:细胞外凋亡途径与中耳胆脂瘤细胞凋亡
- Author:
Songlin PAN
;
Shusheng GONG
;
Hongbin HE
- Publication Type:Journal Article
- Keywords:
Cholesteatoma, Middle Ear;
Caspases;
Apoptosis;
Immunohistochemistry
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the expressions and significance of Fas/APO-1 protein and caspase-3 in human middle ear cholesteatoma and to investigate the relationship between their expressions and the apoptosis of cholesteatoma. METHODS The specimens from the middle ear cholesteatoma tissue of 20 cases and external ear skin of 10 cases were examined by immunohistochemical SP method and TUNEL method. RESULTS There was a significant difference in the expressions of Fas/APO-1 and caspase-3 positive cells between choleseatoma epithelium and normal external ear canal skin(P
