Effect of Zishen Prescription on Learning and Memory Ability of AD Rats
- VernacularTitle:滋肾方对阿尔茨海默病模型大鼠学习记忆的影响
- Author:
Yuan ZHANG
;
Lu ZHANG
;
Bing SUN
- Publication Type:Journal Article
- Keywords:
Zishen prescription;
Alzheimer's disease;
Learning and memory;
Cholinesterase;
Monoaminoxidase
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Zishen prescription on the learning and memory abilities and activities of CHE and MAO in nerve tissues of the AD rats,and discuss the anti-AD effects of Zishen prescription.Methods The subacute aging rat models were made by injecting D-galactose;and then both sides of NBM were damaged with IA according to the brain stereotaxic atlas of rats.The learning and memory abilities were determined by ″Y″ maze;and the activities of CHE and MAO in the hippocampus of rats were tested by spectrophotometer.Results Compared with the results of AD control group,the treatment of Zishen prescription significantly decreased the number of electric stimuli(61.00?11.01 vs 43.70?11.02,P
