The Role of Oxidative Stress in the Experimental Diabetic Nephropathy
- VernacularTitle:氧化应激在实验性糖尿病肾病中的作用
- Author:
Ling WANG
;
Deyong DONG
;
Yue SUN
- Publication Type:Journal Article
- Keywords:
Diabetes;
Nephropathy;
Malondialdehyde;
Superoxide Dismutase
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of oxidative stress in the initiation and development of experimental diabetic nephropathy.Methods Levels of MDA and the total SOD activity were tested in the whole kidney at 1 month,3 months and 6 months of experimental rat diabetes induced by streptozotocin.The pathological changes of diabetic rats were examined by light microscopy.Results The MDA level increased significantly in the diabetic group as compared to control group at all time intervals(2.16?0.57 vs 1.18?0.18,P
