The Detection and its Clinical Significance of Plasma Platelet Microparticles in Type 2 Diabetes
- VernacularTitle:2型糖尿病患者检测血小板微粒的临床意义
- Author:
Lijun RONG
;
Yongsheng CHEN
- Publication Type:Journal Article
- Keywords:
Platelet microparticiles(PMPs);
Flow cytometry;
Type 2 diabetes
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the plasma Platelet Microparticiles(PMPs)level and its clinical significance in patients with type 2 diabetes mellitus(T2DM).Methods Venous blood samples were obtained from 96 of T2DM patients and 30 of non-diabetic control subjects.PMPs,CD61P positive on platelets,were quantified by flow cytometry.Meanwhile,plasma levels of PLT,FPG,TC,TG,HDL-C,LDL-C and LP(a)were detected,as well as the levels of MA and TRF from urine samples.Results PMPs counts were significantly greater in 2 year or up 2 year groups than in controls.PMPs count was associated with levels of urine MA and TRF,but not related with other indexes.Conclusion PMPs may be a marker of microvascular disease in Type 2 diabetes.
