Antiplatelet and Anti-thrombotic Effects of ?-cyclodextrin Inclusion of Dragon's Blood
- VernacularTitle:?环糊精包合血竭对血小板聚集和血栓形成的影响
- Author:
Lichuan YANG
;
Peng CHEN
;
Weiya LEI
;
Jianlin HU
;
Zhihe CHEN
;
Zhiqiang SHEN
- Publication Type:Journal Article
- Keywords:
Dragon's Blood;
?-cyclodextrin;
?-cyclodextrin inclusion of Dragon's Blood;
Thrombosis;
Platelet aggregation
- From:
Journal of Kunming Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate antithrombotic and antiplatelet effects of Dragon's Blood,?-cyclodextrin inclusion of Dragon's Blood.Methods The methods of injection of adenosin diphosphate(ADP) into mouse tail vein,electrically stimulated arterial thrombosis in rats were used to evaluate the anti-thrombotic effects of Dragon's Blood and?-cyclodextrin inclusion of Dragon's Blood,respectively.Platelet aggregation(PRP or washed platelets) was tested according to Born's method.Results ?CYDB significantly protected against thrombosis caused by ADP on mice,and electrical stimulation on rats.In vitro?-cyclodextrin inclusion of Dragon's Blood inhibited AA,ADP,PAF-induced platelet aggregation.Conclusions The results suggest that compared with Dragon's Blood,?-cyclodextrin inclusion of Dragon's Blood has more potent anti-thrombotic effects on the thrombotic models,its mechanisms may be closely related to the inhibition of anti-platelet aggregation.?-cyclodextrin inclusion of Dragon's Blood can improve the bioavailability of Dragon's Blood.
