Behavioral Score of GAP-43 in Rat Acute Complete Spinal Cord Injury
- VernacularTitle:GAP-43对脊髓全横断损伤后的运动功能的影响
- Author:
Yanping DUAN
;
Zhitian SHI
;
Junjie DONG
;
Dingjun HOU
;
Jianyu XIE
;
Ya ZHAN
- Publication Type:Journal Article
- Keywords:
Spinal cord injury;
GAP-43;
Behavioral score
- From:
Journal of Kunming Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the behavioral changes of the spinal cord injury model to provide important data for neuroal factor therapy of the impaired spinal cord.Methods In SD rat,aged 8 weeks,(T7~T8 spinous processes as control),after the spinous process and corresponding lamina of vertebra were removed,the spinal cord was cut by using scissors to prepare the complete transversal abruptly spinal model.The behavioral score of the rat was recorded at different time.The evaluation was made in imageology and pathology.Results The score of SD rat in the experiment group was higher than the control group at different control time.The pathobiology and imageology alterations were very apparent in the damaged spinal area.Conclusion GAP-43 has neuroprotective effect on the recovery of spinal cord injury.
