Effects of Compound LJZ on Antitumor Activity and Immune Function in Tumor Bearing Mice
- VernacularTitle:化合物LJZ对小鼠移植瘤生长和荷瘤小鼠免疫功能的影响
- Author:
Yanli ZHANG
;
Chaixia LI
;
Yuxi JIN
;
Chen QING
- Publication Type:Journal Article
- Keywords:
LJZ;
Antitumor activity;
Immune function;
Mice
- From:
Journal of Kunming Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of compound LJZ on antitumor activity and immune function in mice bearing implanted tumor in vivo.Methods The antitumor effects on the sarcoma 180(S180) and hepatoma 22(H22) bearing in mice were evaluated by weight of tumor.The effects of compound LJZ on specific immunity function were observed by delayed-type hypersensitivity(DTH) response induced by 2,4-dinitro-1-fluorobenzene(DNFB)and the effects of compound LJZ on non-specific immunity function were studied by macrophage phagocytosing neutral red.Results Compound LJZ inhibited significantly the growth of S180 and H22 bearing in mice,and showed dose-dependent relationship.Compound LJZ could enhance the phagocytic capacity of macrophage in bearing S180 mice.But it had no effect on DTH.Conclusion Compound LJZ has significant antitumor effects in vivo,and the effects on phagocytic capacity of macrophage maybe one of its antitumor mechanisms.
