The Expression of PP2Ac in Various Kinds of Lung Carcinomatous tissue and Lung Carcinomatous cells
- VernacularTitle:PP2Ac在人不同类型肺癌组织和肺癌细胞中的表达
- Author:
Caixia LI
;
Ling ZHANG
;
Peng BAI
;
Qinqin WANG
- Publication Type:Journal Article
- Keywords:
PP2Ac;
Lung neoplasms;
p-AKT;
Cell line
- From:
Journal of Kunming Medical University
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05),that there was negative expression of PP2Ac protein in the cytoplasm of the human lung squamous carcer and small cell lung cancer while positive expression of PP2Ac protein in intercellular substance,and that there were negtive expression of PP2A in human lung adencarcinoma and overexpression of p-AKT protein in human lung adencarcinoma.Western blot technique analysis showed that there was nomal expression of PP2A protein in normal human lung tissue,and lower expression in YTLMC-90 cell than in nomal human lung tissue.While sharp low expression GLC-82 cell.Adding okadaic acid(OA),an inhibitor of PP2A,the expressiong of p-AKT in GLC-82 cells was sharply higher than in normal lung tissue at 6 h,12 h and 24 h,indicating that inverse correlation between PP2A and p-AKT protein expression.Conclusions PP2A is involved in human lung carcinomar,its expression level is related to histological type of human lung carcer.Activition of AKT(p-AKT)is related tightly to human lung carcer.
