Effect of Thalidomide on Angiogenesis in Implanted Human Tumors of Nude Mice
- VernacularTitle:反应停对人癌裸鼠肿瘤及新血管形成的影响
- Author:
Hua XU
- Publication Type:Journal Article
- Keywords:
Thalidomide;
OVCAR-3;
HCT-8;
Microvessel density;
Angiogenesis
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of thalidomide in the growth of the human ovarian cancer cells (OVCAR-3) and HCT-8 as well as the angiogenesis in tumor tissue through building a model of heterograft of nude mice with human tumors. METHODS: After implanting human tumors in nude mice for modeling, the inoculated nude mice were intragastrically administered different dose of thalidomide, with tumor growth condition observed and compared with control group. The diversity of microvessel density(MVD) in tumor tissue was detected by immunohistochemistry. RESULTS: Middle and high dose thalidomide could significantly inhibit the growth of OVCAR-3 human tumor in nude mice(P
