Quantitative Determination of Levofloxacin by PVC Membrane Ion-Selective Electrode
- VernacularTitle:聚氯乙烯吡咯烷酮膜离子选择性电极法测定左氧氟沙星的含量
- Author:
Huiping XI
;
Deguang ZHANG
;
Yanzhao LIU
;
Hongtao XIE
- Publication Type:Journal Article
- Keywords:
Levofloxacin;
Ion-selective electrode;
Chemical sensor;
Quantitative determination
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the content of levofloxacin by PVC membrane selective electrode. METHODS: A glass electrode coated with levofloxacin PVC membrane was prepared for the first time with the molecular complex of levofloxacin iodide and bismuth iodide as electric active material, and a series study was performed on its responsibility. RESULTS: The electrode gave Nernst response to levofloxacin over the concentration range of 5.0?10-3～1.0?10-5 moL?L-1 with a slope rate of 56.5mV?pC-1, a suitable pH of 2.5～4.0, and an average recovery rate of 98.31%～101.6%(2.80%～4.90%). CONCLUSION: The electrode was simple in operation, and it has a rapid response and good reproducibility, and it is applicable for the quantitative determination of levofloxacin.
