Determination of Fluvastatin Sodium Extended-release Tablets by HPLC
- VernacularTitle:HPLC法测定氟伐他汀钠缓释片的含量
- Author:
Shaojun ZHANG
;
Feilong XU
;
Guobing ZHANG
- Publication Type:Journal Article
- Keywords:
Fluvastatin sodium extended-release tablets;
HPLC;
Determination of content
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for determining the content of fluvastatin sodium in fluvastatin sodium extended-release tablets. METHODS:An Agilent SB-C18 column was used and the mobile phase was CH3CN-0.1% phosphate acid, 50∶50. Flow rate was 1mL?min-1, wavelength was 234nm and the sample size was 20?L. RESULTS:The fluvastatin sodium concentration had good liner relationship from 4.84～96.8?g?mL-1(r=0.999 9), and the average recovery was 100.1%,RSD=0.9%. CONCLUSION:This method was simple, fast, accurate, and precise, could be used to determine content in fluvastatin sodium extended-release tablets.
