Ulinastatin Administered by Different Routes for Severe Acute Pancreatitis in Rats
- VernacularTitle:乌司他丁不同给药途径对重症急性胰腺炎模型大鼠治疗作用的研究
- Author:
Siyuan LOU
;
Zhengming ZHU
;
Huaqun FU
- Publication Type:Journal Article
- Keywords:
Severe acute pancreatitis;
Ulinastatin;
Celiac arterial perfusion;
Peripheral venous perfusion;
Rat
- From:
China Pharmacy
2007;0(34):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the curative effect and mechanism of ulinastatin (UTI) administered by two different routes for severe acute pancreatitis (SAP). METHODS: 50 healthy male SD rats were randomly divided into 5 groups: sham operation (SO) group (fed with water ad libitum), SAP model group, positive control(nafamostat) group, ulinastatin peripheral venous perfusion group, and ulinastatin celiac arterial perfusion group. SAP model was established in the latter four groups, and then the rats were treated with corresponding drugs. 12h later, sample tissues were taken from pancreas and lungs for measurement of MPO level and histopathologic observation and the blood samples were collected for measurement of serum amylase, TNF-? and TXB2. RESULTS: Levels of amylase, TNF-?, TXB2, MPO and Hughes histopathologic scores of pancreas and lungs in all drug-treated groups were significantly lower than in SAP group (P
