Determination of Ligustrazine Phosphate for Injection by HPLC
- VernacularTitle:HPLC法测定注射用磷酸川芎嗪中主药的含量
- Author:
Caixia LIAO
;
Songmei LUO
;
Yayan ZHU
- Publication Type:Journal Article
- Keywords:
Ligustrazine Phosphate;
HPLC;
Content determination;
Injection
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a HPLC method for the content determination of the principal agent in Ligustrazine Phosphate for injection.METHODS:Ligustrazine Phosphate was separated on Zorbax Extend C18(150mm?4.6mm,5?m).The mobile phase consisted of methanol-water(3∶2).A UV-detector at 295nm was used.RESULTS:The linear range of Ligustrazine Phosphate was 0.21～3.00mg?mL-1(r=0.999 9).The average recovery was 100.1%(RSD=0.93%,n=9).CONCLUSION:This method is simple,accurate,sensitive and reproducible,and it can be applied to the quality control of Ligustrazine Phosphate for injection.
