Effects of Total Saponins of Panax Notoginseng on Oxidative Stress During Atherosclerogenesis in Rabbits Accelerated by Persistent Inflammation
- VernacularTitle:三七皂苷对持续炎症加速兔动脉粥样硬化形成中氧化应激影响的研究
- Author:
Ya LIU
;
Xiaohui LI
;
Haigang ZHANG
;
Yi JIA
- Publication Type:Journal Article
- Keywords:
Total sasponins of Pannax Notoginseng(PSN);
Atherosclerosis(AS);
Inflammatory reaction;
C reactive protein(CRP);
Malondialdehyde(MDA);
Superoxide dismutase(SOD);
Nitric oxide(NO)
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effects of Total sasponins of Pannax Notoginseng(PSN)on oxidative stress during atherosclerogenesis(AS)in rabbits accelerated by persistent inflammation.METHODS:A total of 24 Japanese big-eared rabbits were divided into control group,high lipid group,persistent inflammatory group,and PSN group to be treated accordingly.Serum levels of C reactive protein(CRP),nitric oxide(NO)and malondialdehyde(MDA)as well as the activity of superoxide dismutase(SOD)were given a dynamic monitoring;and aortic atherosclerotic plaque areas were measured.RESULTS:In the persistent inflammatory group,serum levels of CRP and MDA were increased significantly,but SOD activity and level of NO were decreased significantly,aortic atherosclerotic plaque area was increased obviously,and CRP level was positively correlated with both MDA content and plaque area,showing significant difference as compared with the high-lipid group(P
