Preparation and Quality Control of Potassium Dehydroandrographolide Succinate Hollow Suppository
- VernacularTitle:穿琥宁中空栓的制备及质量控制方法研究
- Author:
Haijing LIU
;
Baocheng YU
;
Qiujiang BAI
;
Yehong WU
- Publication Type:Journal Article
- Keywords:
Potassium dehydroandrographolide succinate(PDS);
Hollow suppository;
Preparation;
Ultraviolet spectrophotometry;
Quality control
- From:
China Pharmacy
2007;0(33):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Potassium dehydroandrographolide succinate(PDS)hollow suppository and establish a method for its quality control.METHODS:The PDS hollow suppository was prepared with semisynthesis fatty acid glyceride as ground substances and PEG300 or 1,2 propylene glycol as disperse medium.The content of PDS was determined by ultraviolet spectrophotometry at a detection wavelength of 251nm.RESULTS:The linear concentration range of PDS was 6.0～50.0?g?mL-1(r=0.999 9,n=5).The two kinds of PDS hollow suppository were all up to the quality standard.CONCLUSION:This method is reasonable in design and feasible in technology.
