Frequency and prognosis of extracapsular spread in neck metastasis in supraglottic carcinomas
- VernacularTitle:喉声门上型癌颈淋巴结转移包膜外侵犯的频度和预后
- Author:
Bin LIU
;
Wenyue JI
;
Chao GUAN
;
Zimin PAN
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinoma, Squamous Cell;
Lymphatic Metastasis;
Prognosis
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the frequencyof extracapsular spread (ECS) in neck metastasis and its impact on prognosis in supraglottic carcinoma. METHODS A total of 177 patients with radical or modified neck dissection between Jan. 1994 and Dec. 1997 for supraglottic carcinoma were summarized. Transparent lymph node detection and a series of sectioning method were applied on all neck dissection specimens. The SPSS software package (version 11.5) was used to make statistical analysis. Survival curves were calculated with the Kaplan-Meier model. Impact of extracapsular spread on prognosis was assessed for significance with the Log-Rank test. RESULTS Eighty one patients were pathologically positive in neck specimens and the neck metastatic rate was 45.8 %. ECS was found in 32 cases and the ECS frequency was 39.5 % (32/81). The ECS was related with pathological N stage and the number of positive nodes. Patients with ECS had a higher possibility of regional recurrence and contralateral metastasis. The 5-year survival rates of patients with neck metastasis ECS- and patients with ECS+ were 61.9 % and 22.2 % respectively. The differences had statistically significance. CONCLUSION ECS in neck metastasis affects the prognosis in patients with supraglottic carcinoma. If bilateral neck dissection was not selected simultaneously, close follow-up on contralateral neck should be selected in patients with ECS because of a higher incidence of contralateral neck metastasis.
