Allopurinol in Lowering Serum Uric Acid Level for the Delay of the Progression of Chronic Renal Disease
- VernacularTitle:别嘌呤醇降低血尿酸水平以控制慢性肾病进展的研究
- Author:
Jin LIU
- Publication Type:Journal Article
- Keywords:
Uric acid;
Chronic renal disease;
Allopurinol;
Prospective study
- From:
China Pharmacy
2007;0(32):-
- CountryChina
- Language:Chinese
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Abstract:
OBJECTIVE:To discuss the use of allopurinol for the reduction of serum uric acid level in patients with chronic kidney disease complicating hyperuricacidemia so as to delay the progression of chronic renal disease.METHODS:A total of 47 patients with chronic kidney disease complicating hyperuricacidemia were randomly divided into treatment group and control group:the treatment group was given allopurinol 100～200mg?d-1 in addition to the antihypertensive therapy as adopted in the control group or the common therapy for 12 months.RESULTS:As compared with the control group,serum creatinine level was lower and the rate of renal function deterioration was significantly decreased in the treatment group(P
