Thrombolytic properties of a conjugate of liposomal urokinase with a monoclonal antibody specific for cross-linked fibrin in the model of rabbit artery thrombosis
- VernacularTitle:脂质体包裹尿激酶与D-dimer单抗结合后在血栓模型中靶向溶栓实验
- Author:
Hui YANG
;
Jue WANG
;
Xiaoli DONG
- Publication Type:Journal Article
- Keywords:
D-dimer;
Monoclonal antibody;
Thrombosis;
Thrombolytic therapy
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the targeting thrombolytic effect of a monoclonal antibody specific for cross-linked fibrin connected with liposomal urokinase(UK) in the model of rabbit artery thrombosis.METHODS: Preparation of thrombolytic solutions: with the method of controllable dialysis eradicator in liposomat, empty liposomes, liposomally entrapped urokinase and liposomally entrapped urokinase linked with D-dimer antibody were made. Experiment in vivo: a rabbit thrombosis model of abdominal aorta was induced by ferric chloride. When the blood pressure fall to the lowest, 5 different solutions were separately imported (PBS, maximal-level UK, Ab/Lip/UK, Ab/UK-Lip, Ab-UK-Lip) and observed for 40 min continuously. RESULTS: The varieties of 5 groups blood pressures were analyzed with q-test. Significant differences were observed among Ab-UK-Lip group, maximal-level UK group and others (P
