Nucleostemin gene expression in human breast tumor tissues and its relation with clinical pathology
- VernacularTitle:乳腺肿瘤组织nucleostemin基因表达与临床病理表现的关系
- Author:
Ziwei CAI
;
Xuezhi ZHENG
;
Jing HU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Genes, nucleostemin;
Gene expression
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the expression of nucleostemin (NS) gene in human breast tumor tissues and the relations of NS gene expression level with histological grades, histological types and TNM stages of the tumor.METHODS: Total RNA was isolated from human breast tumor tissue. The methods of electrophoresis and RT-PCR were used in measuring NS gene expression level, and the relations of NS gene expression level with histological grades, histological types and TNM stages of the tumor were analyzed. RESULTS: The results indicated that there was no NS gene expression detected in normal breast tissues, and NS gene expression in malignant breast tumor tissues (P0.05). CONCLUSION: It is suggested that there is no relation of NS gene expression level with histological types of the breast cancer, but there is a marked correlation of NS gene expression level with the histological grades and TNM stages.
