Effect of preoperative transarterial chemoembolization on nephroblastoma
- VernacularTitle:肾母细胞瘤经动脉化疗栓塞术疗效机制探讨
- Author:
Jiaping LI
;
Qi ZHOU
;
Zhi LI
;
Wei CHEN
;
Jianyong YANG
- Publication Type:Journal Article
- Keywords:
Nephroblastoma;
Embolization, therapeutic;
Mitosis;
Apoptosis;
Protein Bax
- From:
Chinese Journal of Pathophysiology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect and mechanism of preoperative transarterial chemoembolization on nephroblastoma.METHODS: Comparative analysis of clinical and pathological features in 39 children with Wilms’ tumor was conducted. TUNEL assay was used to detect the apoptosis of tumor in two groups with or without preoperative interventional treatment. The expressions of P53, Bcl-2 and Bax proteins were detected by immunochemical methods. The patients were followed-up for more than 2 years.RESULTS: The extent of neoplastic cell necrosis and degeneration, interstital fiber tissue hyperplasia of tumor and the number of infiltrating lymphocytes were observed, which were higher in interventional group than those in simple excision group (P
