Nebivolol in the Inhibition of eNOS Activity in Cadiocytes with or without Heart Failure
- VernacularTitle:奈比洛尔抑制心衰和非心衰心肌细胞中一氧化氮合酶活性的作用研究
- Author:
Qiaofeng SONG
;
Chunrong LIU
;
Xizhu WANG
;
Wanning HU
- Publication Type:Journal Article
- Keywords:
Nitricoxide synthase;
Cardiac myocytes;
Nebivolol;
Metoprolol;
Carvedilol;
Beta-receptor
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
0.1), but which were inhibited significantly in the left ventricular cardiac myocytes of the subjects with heart failure(P≤0.05). Both carvedilol and metoprolol exhibited no effect on eNOS activity in all the investigated cardiac myocytes. CONCLUSIONS: Nebivolol does no effect on eNOS activity of left ventricular cadiocytes in subjects or rats without hear failure but it can inhibit eNOS activity of cadiocytes in subjects or rats with heart failure so as to exert its beneficial clinical effect.
