In Vivo and in Vitro Antibacterial Activities of Cefodizime Sodium
- VernacularTitle:头孢地嗪钠体内、外抗菌活性研究
- Author:
Zhi DAI
- Publication Type:Journal Article
- Keywords:
Cefodizime sodium;
Minimal inhibitory concentration;
50% Effective dose;
Antibacterial activity;
Mice
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To evaluate the in vitro and in vivo antibacterial activities of cefodizime from both home and abroad. METHODS: The minimal inhibitory concentrations (MICs) of domestic and imported cefodizime, cefotaxime sodium against 300 clinical isolates of bacteria were tested by standard agar dilution method and the test tube dilution method. The in vivo antibacterial activities of cefodizime were determined in mice with experimental systemic infection caused by E.coli, K. pneumoniae and S.aureus. The values of ED50 were calculated by Bliss method. RESULTS: Both domestic and imported cefodizime had remarkable potency against majority gram- negative bacteria and gram- positive bacteria, including pneumococcus and beta streptococcus, and the MIC90 of cefodizime stood at 0.012～1.0?g?mL-1; and they showed medium grade antibacterial activity against bacillus cloacae, bacillus aerogenes and serratia but mild effects on MSSA and S.epidermidis, and the MIC50 stood at 4?g?mL-1. In this trial, bacillus aeruginosus, acinetobacter, enterococcus and MRSA showed resistance against the domestic and imported cefodizime. The in vivo antibacterial activities of domestic and imported cefodizime were similar and remarkable in mice infected with E.coli, K.pneumoniae and S.aureus. CONCLUSION: Domestic and imported cefodizime had excellent and similar antibacterial activity.
