Dissolution of Sarpogrelate Hydrochloride Tablets
- VernacularTitle:盐酸沙格雷酯片的溶出度研究
- Author:
Youliang WU
- Publication Type:Journal Article
- Keywords:
Sarpogrelate hydrochloride tablets;
Dissolution;
UV spectrophotometry
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To establish a method for the determination of the dissolution of sarpogrelate hydrochloride tablets. METHODS: The dissolution of sarpogrelate hydrochloride tablets was determined by UV spectrophotometry with 0.1mol?L-1 hydrochloric acid as solvent at a rotation speed of 100r?min-1. The sampling time was 30min and the detection wavelength was set at 273nm. RESULTS: The linear range of sarpogrelate hydrochloride together was 3～30?g?mL-1(r=0.999 7) and the average recovery was 100%～100.35%, RSD=0.73%. The dissolutions of three batches of samples were all above 90%. CONCLUSION: The method is simple, accurate and reliable, and it can be used for the determination of the dissolution of sarpogrelate hydrochloride tablets.
