Preparation and Quality Control of Compound Lincomycin Nasal Drops for Children
- VernacularTitle:小儿用复方林可霉素滴鼻液的制备及质量控制
- Author:
Chenmei MAO
;
Yun JIANG
;
Zengyan ZHU
;
Xunwu DOU
- Publication Type:Journal Article
- Keywords:
Compound lincomycin nasal drops for children;
Preparation;
Quality control
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare compound lincomycin nasal drops for children and establish a quality control method for this preparation. METHODS: Compound lincomycin nasal drops for children were prepared using lincomycin hydrochloride as main component with its content determined by polarimetry. The content and stability of the preparation within 12mon under room temperature were investigated. Meanwhile irritating test of rabbits' nasal mucosa was conducted. RESULTS: The prepared eye drops were limpid colorless liquid and it met the related standards stated in China Pharmacopeia(2005 edition) in identification as well as tests etc. Lincomycin hydrochloride showed a good linear relation in the range of 3.2～20.0mg?mL-1(r=0.999 9), with average recovery at 100.6%(RSD=0.69%). This preparation showed a little irritation on nasal mucosa, and it was stable within 12mon under room temperature. CONCLUSIONS: This preparation is simple and feasible in preparation technology and controllable in quality.
