Formula and Preparation Technology of Gliclazide Controlled-release Tablets
- VernacularTitle:格列齐特缓释片处方及工艺研究
- Author:
Wei ZHANG
;
Zhi LIU
;
Wei ZHA
;
Yinying ZHAO
;
Zhiyi ZHANG
;
Xingyu LIU
- Publication Type:Journal Article
- Keywords:
Gliclazide;
Controlled-release tablets;
Formula and preparation technology;
Release rate
- From:
China Pharmacy
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To optimize the formula and preparation technology of gliclazide controlled-release tablets. METHODS: Gliclazide controlled-release tablets were prepared in different formulations and the release rates of the prepared tablets were determined to obtain the optimum formula and preparation technology. RESULTS: The optimized formula of gliclazide controlled-release tablets were determined as follow: with HPMC(K4M)=17g and HPMC(E50)=35g as matrix materials; Calcium hydrogen phosphate=91g as the bulking agent and magnesium stearate as lubricant. Gliclazide controlled-release tablets showed a similar release rate as the reference samples. CONCLUSION: The releasing rate of gliclazide controlled-release tablets prepared in the optimized formula is in line with the standards stated in China Pharmacopeia.
