Spermicidal and Antibacterial Effects in Vitro of Tannic Acid from Chinese Gall
- VernacularTitle:五倍子鞣酸的体外杀精和抑菌作用研究
- Author:
Jianping PENG
;
Jie ZHANG
;
Pengcheng LUO
;
Xianjin DU
- Publication Type:Journal Article
- Keywords:
Chinese gall;
Tannic acid;
Spermicide;
Antibacterial
- From:
China Pharmacy
2007;0(30):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the spermicidal and antibacterial effects of tannic acid from Chinese gall.METHODS:Human sperm samples of 20 subjects were taken for spermicidal tests in vitro in accordance with the standard method recommended by WTO.The minimum inhibitory concentration and minimum bactericidal concentration(MIC and MBC)of tannic acid from Chinese gall on bacterium coli and staphylococcus aureus were detected.RESULTS:The lowest effective spermicidal concentration of tannic acid at 20s was 20mg? mL-1.The MIC and MBC of tannic acid against bacterium coli(3 strains)were 0.195～ 0.390mg? mL-1 and 0.390～ 0.780 mg? mL-1 respectively,against staphylococcus aureus(2 strains)were 0.049～ 0.098mg? mL-1 and 0.195～ 0.390mg? mL-1 respectively.CONCLUSION:Tannic acid from Chinese gall showed potent coagulating effect on spermatines and remarkable antibacterial effect,and which is expected to be an effective and safe vaginal spermicidal and antibacterial agent,further study on which remains to be carried out.
