Fragile histindine triad gene and carcinomas of the nasal cavity and paranasal sinus
- VernacularTitle:脆性组氨酸三联体基因与鼻腔及鼻窦癌相关性研究
- Author:
Yanping ZHANG
;
Wei ZHANG
;
Lina LI
;
Yurui SUN
;
Yan ZHANG
;
Deliang HUANG
- Publication Type:Journal Article
- Keywords:
Nose Neoplasms;
Paranasal Sinus Neoplasms;
Genes;
Loss of Heterozygosity
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the genetic abnormalities of FHIT gene in nasal and paranasal sinus carcinoma, and to explore its relationship between genetic abnormalities of FHIT gene and etiology of nasal and paranasal sinus carcinoma(NPSC). METHODS The clinical data of 48 patients with NPSC treated with radical operations from 1991 to 2000 were studied retrospectively. Patients included 23 female and 25 male ranging in age from 20 to 71 years. Immunohistochemistry with SP method was used to assess the expression of FHIT in the carcinoma specimens of the patients. Microdissection and denaturating high-performance liquid chromatography (DHPLC) were used to analyze the loss of hereteozygosity (LOH) of DS1234 in exon 8 of FHIT gene. RESULTS The loss of expression of FHIT was found in 5 patients(10.4 %, 5/48). Comparing with adjacent non-neoplastic tissue, reduced expression of HFIT was found in 16 (55.17 %, 16/29) patients. The adenoid cystic carcinoma showed stronger expression of FHIT than squamous cell carcinoma(P
