Effects of salicylate on L-type calcium channels in rat inferior colliculus neurons
- VernacularTitle:水杨酸钠对大鼠下丘神经元L-型钙通道的影响
- Author:
Yanxing LIU
;
Xuepei LI
;
Hailin ZHANG
;
Hong LU
;
Xiang QI
;
Huijun ZHANG
- Publication Type:Journal Article
- Keywords:
Sodium Salicylate;
Rats;
Calcium Channels, L-Type;
Tinnitus
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To understand what role of the L-type calcium channels play in the mechanism of salicylate-induced tinnitus. METHODS The effects of salicylate on L-type calcium channels in freshly dissociated inferior colliculus neurons of rats were studied using the whole-cell voltage clamp method. RESULTS Salicylate blocked L-type calcium channel current (ICa,L) in concentration-dependent manner. The half-blocking concentration of salicylate was 1.99 mmol/L. Salicylate did not affect the conductance-voltage curve and the steady-state activation curve of ICa,L, shifted the steady-state inactivation curve of ICa,L by about 8 mV in the hyperpolarizing direction, and delayed the recovery from inactivation of ICa,L. CONCLUSION Our results suggest that salicylate’s blocking of L-type calcium channels may contribute to salicylate-induced tinnitus by decreasing the release of ?-aminobutyric acid in the inferior colliculus.
