Target-controlled Infusion of Midazolam on Conscious Sedation for Patients Undergoing Combined Spinal-epidural Anesthesia
- VernacularTitle:腰-硬联合麻醉下咪达唑仑清醒镇静的研究
- Author:
Jianhui GAN
;
Jie CHEN
;
Xizhu WANG
- Publication Type:Journal Article
- Keywords:
Combined spinal-epidural anesthesia;
Midazolam;
Conscious sedation;
Bispectral index
- From:
China Pharmacy
2007;0(29):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To confirm the feasibility of target-controlled infusion of midazolam on conscious sedation for patients undergoing combined spinalepidural anesthesia and the needed target-controlled blood concentration.METHODS: Sixty patients undergoing combined spinal-epidural anesthesia were subjected to target-controlled infusion of midazolam.The level of sedation of midazolam was evaluated applying OAA/S score and bispectral index(BIS).The correlation between target-controlled blood concentration(Cp) and BIS was determined.The Cp,BIS,MAP,HR and SpO2 at different OAA/S were observed. RESULTS: When OAA/S score was 3,the required target-controlled blood concentration of midazolam was(122.8? 20.8) ng? mL-1 in midazolam sedation patients.There was a good correction between BIS and Cp,and BIS=— 3.28Cp+ 355.22(r=— 0.862 5,P
