Study on bone marrow angiogenic mediators and inhibitors in aplastic anemia
- VernacularTitle:再生障碍性贫血骨髓促血管新生因子与抑制因子的研究
- Author:
Zhenhai ZHOU
;
Xiaoyin LI
;
Juan LI
;
Shaokai LUO
;
Yunxian CHEN
- Publication Type:Journal Article
- Keywords:
Anemia,aplastic;
Angiogenesis factor;
Angiogenesis inhibitors
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: Through detecting bone marrow angiogenic mediators and inhibitors in aplastic anemia(AA) patients,the value of angionesis in AA pathogenesis was elucidated.METHODS: The patients were divided into severe AA group(SAA,8 patients),non severe AA group(NSAA,10 patients),and normal control group(7 persons),5 patients were observed before treating(group beginning) and getting improvement(group improving).The angiogenic mediators vascular endothelial growth factor(VEGF) and bFGF were detected by ELISA,angiogenic inhibitors IFN? and TSP were detected by ELISA and flow cytometry,respectively.RESULTS: The levels of VEGF were lower in SAA group and NSAA group than those in control group significantly(P
