Differential proteomic analysis of liver in apoE/LDLR double-gene mutant mice
- VernacularTitle:ApoE/LDLR双基因突变小鼠肝脏差异表达蛋白组研究
- Author:
Xiaolei JIN
;
Xinghui SONG
;
Xiaoming XING
;
Na WANG
;
Qiang FU
;
Yuping SHI
;
Jie PAN
- Publication Type:Journal Article
- Keywords:
Genes,ApoE/LDLR;
Atherosclerosis;
Liver;
Electrophoresis,gel,two-dimensional
- From:
Chinese Journal of Pathophysiology
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
5 fold) were noted.Six significant differential proteins in gel were identified by LTQ-ESI,e.g.endoplasmin precursor,acidic leucin-rich nuclear phosphoprotein 32 family member A,serotransferrin precursor,stress-70 protein precursor,fibronectin precursor,complement C3 precursor,fibrinogen gamma polypeptide.CONCLUSION: The protein profile of apoE-/-/LDLR-/-mouse liver exhibits significant difference compared to that of WT mice.The results imply that lipid metabolism relative polygenetic mutation contributes to the alteration of mouse liver protein expression profile,especially that lipid metabolism related perhaps participates in dysfunction in lipid metabolism during atherogenesis.
