Effect of Fosinopril on Functions of Endothelial Cell in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Hypertension
- VernacularTitle:福辛普利对中老年2型糖尿病并发高血压患者内皮功能的影响
- Author:
Zhigang ZHAO
;
Jing LIU
- Publication Type:Journal Article
- Keywords:
Fosinopril;
Type 2 diabetes mellitus;
Thromodulin;
Niitric oxide;
von Willebrand factor
- From:
Chinese Journal of Prevention and Control of Chronic Diseases
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of fosinopril on plasma biomarkers of endothelial cell in elderly patients with type 2 diabetes mellitus complicated with hypertension. Methods Fourty-two patients with type 2 diabetes mellitus complicated with hypertension were treated with fosinopril (10～20)mg/d for 6 months. Twenty-four matched healthy people were selected as control. Before treatment and after 6 months of treatment,thromodulin (Tm),von willebrand factor and nitric oxide (NO) as well as systolic pressure (SBP) and diastolic pressure (DBP) were detected. The reactive congestion and nitroglycerin-induced dilation of the right brachial artery were assayed with high-resolution ultrasound. Results After 6 months of treatment in all patients,diameters of brachial artery after taking glyceryl trinitrate showed no change markedly,but the plasma levels of Tm and vW factor were decreased and NO was increased obviously than those before treatment. The diameter of brachial artery in responding to reactive hyperaemia was improved greatly and the SBP & DBP were all decreased obviously than those before the treatment. Concusion Fosinopril effectively reduces blood pressure and the endothelial-dependent vasodilatation companied with decrease of the plasma Tm & vW factor and increase of the plasma NO in patients with type 2 diabetes mellitus complicated with hypertension.
