Preparation Technology of Ketoconazole Calcium Alginate Gel Beads
- VernacularTitle:酮康唑海藻酸钙凝胶小球的制备工艺研究
- Author:
Yanqing ZHANG
;
Junbo XIE
;
Mingchun ZHANG
;
Wuqin QI
;
Wenjie LI
- Publication Type:Journal Article
- Keywords:
Ketoconazole;
Preparation technology;
Formulation optimization;
Calcium alginate;
Gel beads;
Orthogonal test
- From:
China Pharmacy
2007;0(28):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the preparation technique and optimal formulation of ketoconazole calcium alginate gel beads.METHODS:Ketoconazole calcium alginate gel beads were prepared by droplet method.The orthogonal experiment was carried out with encapsulation efficiency(EE)and drug loading(LD)as indexes to optimize the optimal formulation of the calcium alginate gel beads.The encapsulation efficiency and drug loading amount for the optimized formulation were determined,and the optimized formulation was compared with crude drug in respect of the in vitro drug release behavior.RESULTS:The result showed that the optimal formulation was as follows:2.0% Na-alginate and 0.3mol? L-1 CaCl2 with the ratio of Na-alginate:ketoconazole at 2∶ 1.The average EE and LD were(90.53? 2.32)% and(31.51? 2.08)%,respectively,and the slow-release was better as compared with that of the crude drug.CONCLUSION:The preparation procedure is simple,feasible,stable and reproducible.
