Effects of ERC61-Extract from Rhizoma Curcumae on Hematopoietic Functions in Mice Treated by Chemotherapy
- VernacularTitle:莪术提取物ERC61对化疗小鼠造血功能的影响
- Author:
Mao XING
;
Xiaohui LI
;
Haigang ZHANG
- Publication Type:Journal Article
- Keywords:
ERC61;
Chemotherapy;
Hematogenetic function;
Cyclophosphamide(CTX)
- From:
China Pharmacy
2007;0(27):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of ERC61,an extract from Rhizoma Curcumae on hematopoietic functions of mice pretreated by cyclophosphamide(CTX) and the proper regime of the administration of ERC61.METHODS:The experimental mice were treated with CTX(100mg? kg-1? d-1) by ip for 3 consecutive days to establish leucopenia model.ERC61 was ip administered to the prevention group,the treatment group,and the combined group(prevention+ treatment).The numbers of blood leucocytes and bone marrow cell were counted by conventional methods;spleen index was measured as well.RESULTS:ERC61 enhanced the count of leucocytes and nucleated cells in bone marrow and improved the level of spleen index.CONCLUSION:ERC61 is able to improve the disorders of hematopoietic functions induced by CTX,and the combination therapy of prevention and treatment is the optimum one in efficacy.
