Function of MMP-2 and TIMP-2 in laryngeal carcinomas and the relationship among expression of MMP-2, TIMP-2 and microvessel density
- VernacularTitle:喉癌MMP-2和TIMP-2表达与瘤内微血管密度的相关性
- Author:
Pingdong LI
;
Zhenkun YU
;
Zhigang HUANG
;
Jugao FANG
;
Xin NI
;
Qi WANG
;
Erzhong FAN
;
Yanshun DU
;
Liping ZHAO
;
Ying LI
- Publication Type:Journal Article
- Keywords:
Laryngeal Neoplasms;
Carcinoma;
Gelatinase A;
Tissue Inhibitor of Metalloproteinase 2;
microvessel density
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To understand the function of MMP-2 and TIMP-2 and the relationship among expression of MMP-2, TIMP-2 and microvessel density in laryngeal carcinomas. METHODS The expression of MMP-2, TIMP-2 and CD34 in 37 laryngeal carcinomas patients were studied with immunohistochemical staining. The staining results were studied morphometrically with computer image analysis. RESULTS The mean values of MMP-2 expression and microvessel density (MVD) in squamous cell carcinoma group with lymph node metastasis were significantly higher than that without lymph node metastasis (P
