Hypothermic ventricular fibrillation with left ventricular drainage under cardiopulmonary bypass on canine lung preservation without aortic-cross clamping
- VernacularTitle:不阻断升主动脉低温室颤左室引流技术对犬肺组织保护作用的实验研究
- Author:
Zhanqing LI
;
Xiaohai GUAN
;
Xue YI
;
Ligang LI
;
Guohua PU
;
Chen CHEN
;
Yu ZHANG
;
Guosheng CHEN
- Publication Type:Journal Article
- Keywords:
Hypothermic ventricular fibrillation;
Lung injury;
NF-kappa B;
Intercellular adhesion molecule-1;
Interleukin-8;
Extracorporeal circulation
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the protective effect of hypothermic ventricular fibrillation without aortic-cross clamping under cardiopulmonary bypass(CPB)on canine lung.METHODS:Fourteen dogs were randomly divided into two groups.All dogs received a standardized anesthetic technique.A conditional CPB was performed in every instance.Ventricular fibrillation was induced by systemic hypothermia to 28 ℃ and pericardial cooling saline in the experimental group.A standard CPB was performed in control group.The concentration of IL-8 in serum was measured by ELISA.The expressions of NF-?B and ICAM-1 were determined by using immunohistochemical staining.RESULTS:Serum IL-8 level in experimental group was significantly lower than that in control group(P
