Change of insulin-like growth factor-2 in obstructive sleep apnea-hypopnea syndrome
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征外周血IGF-2及其mRNA水平变化的初步研究
- Author:
Huiguo LIU
;
Mei LIN
;
Pin GUAN
;
Yongjian XU
- Publication Type:Journal Article
- Keywords:
Sleep apnea syndromes;
Insulin-like growth factor Ⅱ
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe the change of insulin-like growth factor-2(IGF-2)in patients with obstructive sleep apnea-hypopnea syndrome(OSAHS),and to explore the relationship of IGF-2,OSAHS and cardiovascular disease complicated with it.METHODS:The level of serum IGF-2 in 40 OSAHS patients and 20 healthy controls was measured by enzyme-linked immunosorbent assay(ELISA).The expression of IGF-2 mRNA in peripheral blood mononuclear cells was detected by reverse transcription polymerase chain reaction(RT-PCR).RESULTS:The serum level of IGF-2 and the expression of IGF-2 mRNA in peripheral blood mononuclear cells were significantly higher in OSAHS group than those in control group(P
