Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats
- VernacularTitle:阿托伐他汀对移植动脉慢性排斥反应的抑制作用及机制
- Author:
Xingjun GUO
;
Zifang SONG
;
Qichang ZHENG
;
Lei ZHANG
;
Keqiang ZUO
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Transplantation;
Graft rejection;
Proliferating cell nuclear antigen;
Nitric oxide
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats.METHODS:The models of abdominal aorta transplantation were made with micro-surgery in rats.The recipients were divided into three groups:allograft control group,atorvastatin-treated group and isograft control group.Vascular intimal thickness in all of the groups was observed by histological examination.The expression of proliferation cell nuclear antigenl(PCNA)and ?-smooth muscle actin(?-SMA)were determined by immunohistochemistry.The content of nitric oxide was measured by nitrate reductase chromatometry.RESULTS:The vascular intimal thickness in atorvastatin-treated group(11.60%?2.40%)was lower than that in allograft control group(34.60%?6.40%,P
