Relationship between matrix metalloproteinase-9 and tissue metalloproteinase inhibitor-1 and carotid atheromatous plaque stability
- VernacularTitle:基质金属蛋白酶-9及其组织抑制物-1与颈动脉粥样斑块稳定性相关研究
- Author:
Feng GAO
;
Shuijiang SONG
;
Jimin WU
;
Shuqun WEN
;
Guodong ZHONG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Carotid atheromatous plaque;
Gelatinase B;
Tissue-inhibitor of metalloproteinase-1
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the correlation between matrix metalloproteinase-9(MMP-9),tissue metalloproteinase inhibitor-1(TIMP-1),MMP-9/TIMP-1 and carotid atheromatous plaque stability in cerebral infarction patients.METHODS:80 patients with cerebral infarction were categorized as microemboli-negative group(n=70)and microemboli-positive group(n=10),20 normal human were served as control group.The MMP-9 and TIMP-1 levels in plasma were determined by mean of ELISA in 3 groups.RESULTS:The levels of MMP-9 and TIMP-1 in plasma were significantly higher in cerebral infarction patients than those in control group(P
