Study on the damage of auditory path of the experimental autoimmune encephalomyelitis
- VernacularTitle:实验性自身免疫性脑脊髓炎脑干听觉通路损害的研究
- Author:
Wei ZHANG
;
Li ZENG
;
Jiaxin LI
;
Wanxing LU
- Publication Type:Journal Article
- Keywords:
Encephalomyelitis,experimental autoimmune;
Auditory pathways;
Brain stem
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To explore if there is lesion in the auditory path in the brainstem of the Wistar rat with experimental autoimmune encephalomyelitis(EAE).METHODS:EAE was induced by guinea pig spinal cord homogenate(GPSCH),then the evoked potential in both EAE and control groups was examined.The HE staining and myelin staining of the auditory nucleus were conducted in order to corroborate the damage of the auditory path in the brainstem.Through studying the pathological changes using light microscopy and behavior changes of rats,we defined that the model was successful.RESULTS:The latency period of auditory evoked potentials of EAE rats was much longer than that in control group.The pathological pictures manifested that auditory nucleus were invaded by a great number of lymphocytes,demyelinations were discovered in it.CONCLUSION:The auditory path in the brainstem of the Wistar rat with EAE is suffered from inflammation and demyelination.
