Relationship of expression of extracellular matrix metalloproteinase inducer and hepatocyte growth factor with lymphoid metastasis and prognosis in non-small-cell lung carcinoma
- VernacularTitle:非小细胞肺癌中EMMPRIN和HGF的表达及其对淋巴结转移和预后的影响
- Author:
Huizhong ZHANG
;
Mei WANG
;
Yiping WEI
;
Yongke CAO
;
Haigang LI
;
Ju CHEN
;
Yanqi YANG
;
Ping HUA
;
Cheng WU
;
Jingeng LIU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Extracellular matrix metalloproteinase inducer;
Hepatocyte growth factor;
Lymphatic metastasis;
Prognosis
- From:
Chinese Journal of Pathophysiology
1999;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the expression of extracellular matrix metalloproteinase inducer(EMMPRIN)and hepatocyte growth factor(HGF)in non-small-cell lung carcinoma(NSCLC)and their relationship with lymphoid metastasis and prognosis.METHODS:Expression of EMMPRIN and HGF in 77 cases of patients with NSCLC was detected immunohistochemically.The relationship of expression of EMMPRIN and HGF with tumor size,smoking,histological type,differentiation,lymphoid metastasis,clinical stage,and prognosis was analyzed.RESULTS:The expressive rates of EMMPRIN and HGF were 68% and 44%,respectively.The expressions of EMMPRIN and HGF were associated positively with lymphoid metastasis(r=0.371 and 0.339,P0.05).The expression of EMMPRIN was associated with the expression of HGF in NSCLC.CONCLUSION:The expression of EMMPRIN and HGF is associated with lymphoid metastasis and prognosis in NSCLC.Overexpression of EMMPRIN and HGF implies infavourable prognosis in NSCLC.
