Expression of cyclooxygenase-2 and vascular endothelial growth factor in gastrointestinal stromal tumor and its clinical significance
- VernacularTitle:环氧化酶-2和血管内皮生长因子在胃肠道间质瘤中的表达及其意义
- Author:
Ruizheng MIAO
;
Yueping LI
;
Xiaobo YU
;
Jianfeng LI
;
Naiqing LIU
;
Yanming JIANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Cyclooxyganase-2;
Vascular endothelial growth factor
- From:
Chinese Journal of General Surgery
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) with the growth pattern,malignant degree,metastasis and prognosis of gastrointestinal stromal tumor(GIST).Methods The expression of COX-2 and VEGF was examined with immunohistochemistry from paraffin-embedded tissue sections of 54 patients with GIST,and special attention was given to analyze the relationship between COX-2、VEGF expressions and clinicopathologic factors of the neoplasm.Results The expression of COX-2 and VEGF was significantly higher in malignant GIST than in benign and potentially malignant GIST(P
