Protective Effect of Nimesulide on Experimental Gastric Ulcer in Rats
- VernacularTitle:尼美舒利对胃溃疡模型大鼠的保护作用研究
- Author:
Jin ZENG
;
Ling ZENG
- Publication Type:Journal Article
- Keywords:
Nimesulide;
Indometacin;
Gastric ulcer;
SOD;
MDA;
GSH
- From:
China Pharmacy
2007;0(25):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P
